【Major points】
  1. Hepatitis B vaccine is a synthetic inactive vaccine that is effective in preventing hepatitis B infection.
  2. All newborns are recommended to receive a three-dose series vaccination scheduled at birth, 4 weeks and 6 months old.
  3. Infants who are born weighing less than 2000 grams (2 kg), with respiratory problems, a congenital deformity or other serious illnesses  are not recommended to get Hepatitis B vaccination.
  4. It is common to have a mild fever and/or soreness or swelling at injection site after vaccination.
  5. Rest and oral hydration are recommended after vaccination.

What is hepatitis B vaccine?
  1. Characteristic: An artificial inactive vaccine genetically engineered to prevent hepatitis B infection.
  2. Inoculation method: intramuscular injection.
  3. Dosage: 0.5cc each time 
  4. All children should get the first dose within 24 hours after birth, second dose at 1 month, and third dose at 6 months, for three doses in total.

What are the contraindications?
  1. Infants born weight less than 2000 grams (2 kg).
  2. People who have respiratory problems, heart function impairment, severe jaundice (total bilirubin >15mg/ml), coma, seizures or other severe illness(es).
  3. Congenital deformity or severe organ impairment.
  4. Acute fever.

Reaction after get vaccinated:
  1. Adverse effects rarely happen. Localized soreness is the most common.
  2. Swelling and redness of injection site may happen after vaccination. 
  3. Mild fever may also occur.

Self-care after vaccination:
  1. Drink plenty of water after vaccination.
  2. Rest as much as possible after vaccination.
  3. If there is any severe discomfort or anything of concern, please visit your doctor for further evaluation.
  1. Cheng, Z. Y., Wu, Y. L.& Lin,F.Y.(2021). Pediatric care of Infectious Diseases. In Chen, Y.Z. (Ed.), Practical pediatric care (9th ed., pp274-286).Taipei: Hua Xing press.
  2. Health Promotion Administration, Ministry of Health and Welfare. (2021). Children’s Health Handbook. Taipei City: Health Administration, Ministry of Health and Welfare.
  3. Wu,Y.R. (2020). Travel medicine vaccine review. In Huang, G.J. (Ed.), Travel medicine clinic essentials( pp132-147).Training Center for Travel Medicine CDC.Taiwan & NTUH press.
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